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Research summary

Our view of microglia has changed dramatically in recent decades. We now know that these innate immune cells are essential for brain development, maturation, activity, plasticity and integrity—as well as behaviour and cognition across the lifespan. As Canada Research Chair in Neurobiology of Healthy Cognitive Aging, Dr. Marie-Ève Tremblay is studying how lifestyle, environment, disease and treatment strategies affect microglia as we age. 

She and her research team are focusing on environmental risk factors, such as chronic psychological stress and viral infections, as well as disease processes, such as Alzheimer’s disease. They are also investigating differences between sexes. Using a combination of cutting-edge genetic and environmental mouse models, longitudinal behavioural testing, correlative microscopy, and multi-omics, their research will contribute to innovative therapies that target microglia to promote brain resilience and healthy cognitive aging.